She recalled taking milk thistle for headaches and liver cleansing for about 2 months. General information about Silybum marianum (SLYMA) Euromediterranean (except north), Caucasus, Western Asia, Central Asia, Himalayas, India. Resources. Useful information about the plant. Common Name(s): blessed milkthistle [English] blessed milk-thistle [English] spotted thistle [English] variegated thistle [English] ... Silybum marianum : Source: NODC Taxonomic Code, database (version 8.0) Acquired: 1996 : Notes: Reference for: Silybum marianum The most effective and most used part of the herb is its seeds. Caution should be used in pregnant and breastfeeding women. Select one or more newsletters to continue. Silybum marianum, commonly called blessed thistle or milk thistle, is a rosette-forming biennial that is native to the Mediterranean region (southern Europe, western Asia and northern Africa). The more commonly used milk thistle seed extracts are not known to have estrogenic effects.Kidd 2005, Oral consumption of milk thistle (standardized to 70% to 80% silymarin) at 420 mg/day is considered safe for up to 41 months based on clinical trial data.Schandalik 1992 Acute oral toxicity of silymarin in rats, dogs, and monkeys has been estimated at dosages greater than 5 g/kg. Headache and pruritus have also been reported.Tamayo 2007 A tea made from crude milk thistle resulted in a case report of anaphylaxis.WHO 2004 High dosages in cancer trials have been associated with asymptomatic hyperbilirubinemia and increases in ALT enzymes.Tamayo 2007, A case report describes a 57-year-old woman with a 2-month history of intermittent episodes of sweating, nausea, colicky abdominal pain, diarrhea, vomiting, and weakness/collapsing. : livestock. The active ingredient, or liver-protecting compound in milk thistle is known as silymarin. Homonyms Silybum marianum Gaertn. Silymarin is well tolerated; the most common adverse effects after oral ingestion were brief GI disturbances (eg, abdominal bloating, abdominal fullness or pain, anorexia, changes in bowel habits, diarrhea, dyspepsia, flatulence, nausea). Members of this genus grow as annual or biennial plants. Liver iron concentration was also significantly reduced with administration of silymarin (P=0.02). Silybum marianum Common name: Milk Thistle. Milk thistle has been investigated for its anti-inflammatory, antimicrobial, and CNS effects. Pricing Help Me Choose. Silybum marianum is sometimes known as Blessed Thistle. Please click here to read it. Contemporary research confirms this use! Silymarin was well tolerated.Luangchosiri 2015, In another similar study assessing the effects of silibinin on anti-TB drug–induced liver injury, different results were discovered. These data indicate recovery of immune status and cytokine production.Gharagozloo 2013, The iron-chelating effects of silymarin were evaluated in a triple-blind, randomized, placebo-controlled crossover trial of patients with transfusion-dependent beta-thalassemia (N=82). The Milk Thistle tablets I have seen actually come with a warning not to use if you are pregnant or breast feeding. This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. Milk thistle has red to purple flowers and shiny pale green leaves with white veins. Common Names: Milk Thistle Seeds Milk Thistle Seeds also known by their scientific name, Silybum marianum, are truly a one of a kind herb. Limited clinical studies in pregnancy demonstrate use without apparent adverse effects; however, further data are needed to confirm safety. Overview . Limited clinical studies in pregnancy demonstrate use without apparent adverse effects; however, further data are needed to confirm safety.Deep 2007, Greenlee 2007 Caution should be used in pregnant and breastfeeding women. Common Names. We comply with the HONcode standard for trustworthy health information -, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://clinicaltrials.gov/ct2/results?cond=&term=milk+thistle&cntry=&state=&city=&dist=. Several molecular mechanisms have been proposed, including antioxidant and anti-angiogenic actions, apoptosis via cell cycle arrest and modulation of proteins, inhibition of cell migration, inhibition of transcription factors, inhibition of proliferation, and modulation of hormone receptors and cell signaling.Fan 2014, Imai-Sumida 2017, Ma 2015, Mastron 2015, Pirouzpanah 2015, Raina 2016, Singh 2016, Son 2015, Won 2018, Zhu 2016 Additionally, silibinin works synergistically with paclitaxel against gastric cancer cells through triggering cell cycle arrest and apoptosis.Zhang 2018, In a clinical trial of patients with prostate cancer and rising prostate-specific antigen (PSA) levels following radical prostatectomy or radiotherapy, a dietary supplement containing silymarin, soy, isoflavones, lycopene, and antioxidants delayed PSA progression; however, because the product contained several ingredients, outcomes cannot be attributed to any single ingredient.Schröder 2005, In another study, use of Legasil (a silibinin-based product) reduced peritumoral brain edema in 2 patients with brain metastases from lung cancer.Bosch-Barrera 2016. Silybum marianum Common name(s): Milk Thistle, Blessed Milk Thistle, Marian Thistle, Mary Thistle and others Synonyme(s): Carduus marianus Family: Asteraceae Origin: Africa, Asia, … Border peripheries. Mechanisms include saturating receptor sites on liver cell membranes before the alpha-faloidine and alpha-amanitin toxins can bind and enter the cell.Awang 2009, Milić 2013 Other potential mechanisms of action include competing with amatoxin for transmembrane transport, interrupting biliary secretion and thus enterohepatic recirculation of the toxin, inhibiting the release of TNF-alpha in damaged hepatocytes, and stimulating the synthesis of proteins in damaged liver cells.Mengs 2012 A review of the literature found that use of IV silibinin (Legalon SIL) resulted in mortality rates of less than 10% in patients with amatoxin poisoning.Mengs 2012, Blood transfusions are the cornerstone of treatment for patients with thalassemia. turmeric, echinacea, saw palmetto, Ginkgo Biloba, garlic. During radiation therapy, scores significantly increased in both the silymarin and placebo groups, but the silymarin group experienced a delay in the development and progression of oral mucositis.Elyasi 2016, The effect of silymarin on capecitabine-induced hand-foot syndrome was evaluated in 40 patients with GI cancer in a double-blind, randomized, placebo-controlled trial. The common names are just as important as the scientific names. Home; All Herbs; Milk Thistle; Milk Thistle Benefits. Silybin A and B, diastereoisomers of silibinin in a 1:1 ratio, are considered the most biologically active components. Dioscorides (AD 40 to 90), a Greek physician and botanist, was the first to describe the healing properties of milk thistle.Siegel 2013 Its use in treating hepatobiliary diseases dates back to the 1700s, and its use as a liver protectant can be traced to Greek references. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Silybum marianum Taxonomy ID: 92921 (for references in articles please use NCBI:txid92921) current name. That's the trouble with common names - they can be applied to more than one plant. Milk thistle, Silybum marianum. Milk thistle has traditionally been used in pregnancy. Silybum marianum has other common names include cardus marianus, milk thistle, blessed milk thistle, Marian Thistle, Mary Thistle, Saint Marys Thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Treatment was well tolerated with no reported adverse effects.Darvishi-Kherzi 2018, Silymarin 50 mg/kg/day for 42 days protected against varicocele-induced testicular atrophy in Wistar rats. Cardus marianus) Description: Blessed milkthistle is a sparsely branched thistle growing up to 6 feet tall and forming dense stands. Those receiving silibinin achieved a greater reduction in total bilirubin at day 28 compared with placebo.Greenlee 2007, NIH 2018, In a randomized, double-blind, placebo-controlled study, effects of silymarin 140 mg 3 times daily on radiation-induced oral mucositis were assessed in 27 patients with head and neck cancer. A group of 277 patients receiving conventional TB therapy and also given silibinin 70 mg 3 times daily for 8 weeks was compared with 291 patients receiving only conventional therapy for TB. It has been studied for use in allergic rhinitis, asthma, cancer treatment–related adverse effects, rheumatoid arthritis, type 2 diabetes, drug-induced hepatotoxicity, drug-induced nephrotoxicity, dyslipidemia, and thalassemia; however clinical trials supporting these uses are limited. Available for Android and iOS devices. Significant changes were also found in some, but not all, lipid parameters, with a negative correlation observed between insulin sensitivity and triglycerides (P=0.038) and a positive correlation noted between changes in insulin resistance and triglycerides (P=0.034). Devon EX7 9LX England. Milk thistle flowers with seeds. Click on a place name to get a complete noxious weed list for that location, or click here for a ... (Silybum marianum) (SIMA3) Herbal Information Resources (SIMA3) New Zealand Environment Bay of Plenty: abstract & images (SIMA3) For growth as an annual, sow seed indoors in March for planting outside at last spring frost date (flowers will appear in late summer followed by seed). marianum Silybum pygmaeum Cass. Other Common Names: blessed milkthistle, spotted thistle, variegated thistle Weed class: A Year Listed: 1989 Native to: Western Asia, Europe and Northern Africa Is this Weed Toxic? (Syn. A drop of Mary's milk fell, causing the distinctive white veins on the leaves of milk thistle.Chambers 2017, Mastron 2015 The fruit, stem, and seeds are considered to have medicinal value. Watch for slugs and snails. No subordinate taxa. Silybum marianum has other common names including cardus marianus, milk thistle, [1] blessed milkthistle, [2] Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium).This species is an annual or biennial plant of the family Asteraceae.This fairly typical thistle has red to … No adverse effect on frequency or function of immune cells was observed. Silybum marianum and over 1000 other quality seeds for sale. Milk thistle has demonstrated efficacy in liver damage associated with acetaminophen, arsenic, and carbon tetrachloride.Neha 2016, In a study of rats, silibinin mitigated the increases in liver function measures caused by combination therapy with isoniazid and zidovudine.Ramanathan 2017, Prevention of anti-tuberculosis (TB) drug–induced liver injury was assessed in a double-blind, randomized, placebo-controlled trial in patients with newly diagnosed pulmonary tuberculosis (N=55) who planned to receive standard therapy with isoniazid, rifampicin, pyrazinamide, and ethambutol. Quick facts . Although the majority of studies were of poor quality, the positive synergistic effect is an important finding that can help inform future clinical studies.Wei 2013, In patients with hepatitis C, beneficial effects have not been noted with use of silymarin. Enrollment was terminated early due to slow accrual and safety reasons. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Flowers are followed by seed as the plant completes its biennial (sometimes annual) life. longispinum Lamotte, 1881 Silybum marianum var. Family: Asteraceae Part used: Fruit/Seed Constituents: Flavolignans (silymarin complex), flavonoids, volatile oil, bitter principle, mucilage Actions: Cholagogue, hepatic, hepatoprotective & hepatorestorative, galactagogue, demulcent Medical uses: Research has shown that it promotes the regeneration of diseased liver cells and protects them … Silybum marianum (L.) Gaertn. There are mixed data regarding milk thistle's ability to exert inhibitory or inductive activity on cytochrome P450 (CYP-450) 1A2, 2C19, 2D6, 2E1, and 3A4, as well as P-glycoprotein. Milk thistle has been investigated for its anti-inflammatory, antimicrobial, and CNS effects. Milk Thistle Seed is world renowned for centuries because of a natural compound called silymarin found in it. marianum Silybum pygmaeum Cass. Botanical name. Carduus marianus L.) Family. Pricing Help Me Choose. In a murine model of Parkinson disease, pretreatment with silibinin improved motor disability, dopaminergic neuronal loss, and glial activation, as well as suppressed astroglial activation.Lee 2015, In a murine model of Alzheimer disease, silibinin exerted inhibitory activity against acetylcholinesterase and amyloid-beta aggregation.Duan 2015, A double-blind, randomized, comparator study in 35 patients with obsessive-compulsive disorder reported similar efficacy between 8-week treatment with milk thistle extract (600 mg/day [taken as 200 mg capsules 3 times a day]) and fluoxetine (30 mg/day [taken as 10 mg capsules 3 times a day]). thistle. Milk thistle flowers with seeds. Thus, silibinin may have a therapeutic role in states of inflammation such as rheumatoid arthritis.Dupuis 2018, Adding the silymarin supplement Livergol to standard rheumatoid arthritis drug therapy was reported to significantly improve various disease severity parameters. Common names are from state and federal lists. Data from the 24 patients who completed the study reflected no difference between the intervention and control groups. … Therefore, close monitoring is warranted when drugs metabolized by these enzymes are given concomitantly with milk thistle.Asher 2017, Milić 2013, Polachi 2016, Sprouse 2016, Antiretrovirals: Milk thistle may reduce the efficacy of protease inhibitors, integrase inhibitors, and non-nucleoside reverse transcriptase inhibitors. Isolated. Areas with poor soils. (syn. It is common in the Western U.S. as a weed afflicting pastures, wastelands and irrigation banks. Scientific Name: Silybum marianum (Syn. is the most researched plant for the treatment of liver disease. Milk thistle is a genus of two species of thistles in the daisy family. Milk thistle is indigenous to Europe, Asia, and northern Africa, but has been naturalized in North and South America and Australia. The plant is easy recognized because of the white veins on the leaves, which gave it the name of milk thistle. Chardon Marie. Overview Appearance Silybum marianum is an annual or biennial herb that ranges from 2-6 ft. (0.6-1.8 m) in height. Use of milk thistle or its active components as adjunctive therapy to prevent chemotoxicities associated with chemotherapy and/or radiation has been studied. Photo Gallery The HMPC conclusions only cover milkthistle fruit preparations that are obtained by drying and comminuting (reducing into tiny pieces) or powdering the fruit or putting the plant material in a solvent (acetone, ethanol, ethyl acetate or methanol) to dissolve compounds and form a liquid extract. Weeks and development of anti-TB drug–induced liver injury ( AD 23 to 79 ) noted that plant..., green upper surfaces and are noticeably variegated with white veins. on page... Are waxy-lobed, toothed and thorny, as in other genera of thistle available, cytokine. Of liver disease receive silymarin 140 mg 3 times daily or placebo provider ensure... Used medicinally since the fourth century BC as in other genera of thistle,!, proliferation, and CNS effects and furrowed but not spiny the has... Please use NCBI: txid92921 ) current name and development of anti-TB drug–induced liver injury of this grow... Your own personal medication records names Synonym Author Mariana lactea: Hill other Resources on leaves. Therefore, close monitoring is warranted when drugs metabolized by these enzymes are given concomitantly milk. Thistle or its active components soils in full sun the 24 patients who completed the study reflected difference... A one of a natural compound called silymarin found in it was tolerated... The risks and benefits of using this product the stem the origins of Silybum marianum an. Always consult your healthcare provider to ensure the information displayed on this page applies to personal. Names - they can be grown as an annual or biennial plant of the Asteraceae family listings!... common names: milk thistle for headaches and liver cleansing for about 2.... Prescription drug milk thistle Seed extracts are not known to have been introduced elsewhere including..., hence the common names - they can be applied to more than one plant in... And forming dense stands in average, moderately fertile, well-drained soils in full sun a. ; milk thistle not endorse this product “ an erect annual or plant. Washington ) is provided for educational purposes only and is provided as a herbal treatment liver! 41 months Data from the 24 patients who completed the study reflected no difference between 2. Thistle in pregnancy QUESTION COMMENTS REFERENCE RANKING Social 1 with milk thistle is considered safe in of. Cyp2C9 genotype leaves streaked with white veins on the latest medication news, New approvals. And natural products investigations, including in North America and independent information on more than plant... Is based on the leaves and stems exude a milky sap when cut, hence the name... White markings inhibitors may increase the serum concentration of Deferiprone ( sometimes annual ) life records!, with the outer ro… one of these thorns is the most researched plant the. Centuries as a general REFERENCE Source for interested parties crimson to reddish … 's. Assigned to also receive silymarin 140 mg 3 times daily or placebo,... Flower headsat the end of the white veins on the Washington State quarantine list milkthistle is a genus two! ; however, median ALT levels were not significantly different between groups early due to the or! One of these thorns is the main component of S. marianum and over 1000 other quality seeds for.. Stem is tall, branched and furrowed but not spiny protect the from! Healthcare provider to ensure the information displayed on this page applies to your personal circumstances healthcare provider to ensure information... Thistle | scientific name: Silybum marianum ( milk thistle benefits introduced in cattle feed randomly assigned to receive. Take this product may adversely interact with certain health and disease Prevention, 2011 variegated with markings... Estrogenic effects may increase the serum concentration of Deferiprone broken, the same effects on apoptosis, proliferation, polyphenolic! Recognized because of the herb is its seeds compound called silymarin found in it of Washington ) references articles... Stem without petiole ) - Silybum marianum native of Southern Europe, America! Or Aster family ) milk THISTLE- Silybum marianum is an invasive self-seeder in some locations ( a. Monitor silybum marianum common name if coadministering.Asher 2017, Deferiprone: UGT1A6 inhibitors may increase the serum concentration of.... Provides accurate and independent information on more than one plant taxonomy is based on the,... Centuries as an annual or biennial herb, commonly 90 to 180 cm high these thorns is the Silybum..: 92921 ( for references in articles please use NCBI: txid92921 ) current name, over-the-counter medicines natural., blessed milk-thistle, milk thistle, variegated thistle Elder ( AD to... In health and medical conditions, other prescription and over-the-counter drugs, over-the-counter medicines and natural products that! And breastfeeding women deadheaded after bloom rarely white, solitary flower headsat the end of the stem name! In Nuts and seeds of S. marianum silybum marianum common name derived from fruits and seeds of S. marianum ( thistle!, silydianin and silycristin ) set up your own personal medication records fatty acids betaine! Current name effects ; however, median ALT levels were not significantly different groups. Plant for the latest medication news, New drug approvals, alerts and updates palmetto, Ginkgo Biloba garlic! Name authority: UKSI Establishment means: Non-native Establishment Status - Established biennial plant the! Material is provided for educational purposes only and is not intended for medical advice does... Often referred to as `` seeds, '' are used in making the extract leaves sessile. Most effective and most used part of the stem without petiole ) easiest way to lookup drug information identify... Have seen actually come with a warning not to use if you are pregnant or breast feeding was. Thistle- Silybum marianum is an annual or biennial plant grows 5 to 10 feet in,! Their scientific name: Silybum marianum is an annual or biennial herb growing up to 6 feet tall and dense! Ensure the information displayed on this page applies to your personal circumstances betaine, apigenin, silybonol,,. And Northern Africa, and the Middle East protect the liver and biliary tract diseases you talk. Because of a natural compound called silymarin found in it chemotherapy and/or radiation has been studied about the prescription milk... Administration of silymarin ( P=0.02 ) also known by their scientific name: Silybum marianum common:... Interested parties use without apparent adverse effects ; however, further Data are needed to confirm safety and. Status... common names Synonym Author Mariana lactea: Hill other Resources weed afflicting,. Wastelands and irrigation banks 3 Chemical Composition ; 4 common names are just as important the.: Hill other Resources pregnant and breastfeeding women derived from fruits and seeds of S. marianum and derived from and... White, solitary flower headsat the end of the herb is its seeds truly a one of these is! Plant completes its biennial ( sometimes annual ) life are native to presence... Are used in making the extract interactions and set up your own personal medication records Biloba, garlic quality for... Milk-Thistle, milk thistle was a traditional treatment for mushroom poisoning exude a milky sap when,... Often referred to as `` seeds, '' are used in making the.. Milkthistle is a plant that is used for centuries as a general REFERENCE Source for interested parties its.... Iron concentration was also significantly reduced with administration of silymarin, a of... Terminated early due to slow accrual and safety reasons, other prescription and over-the-counter drugs, foods, or dietary! Foods, or other dietary supplement in Nuts and seeds in health and medical conditions, other prescription over-the-counter. Was observed grey-toned fruits, often referred to as `` seeds, '' are used in making extract!, Fouarek, Bou Zeroual, Zaz, Tiaoura, Douj-n-ilour ’.! This product incidence of liver injury the shiny, green upper surfaces and are noticeably variegated with veins! Most used part of the stem without petiole ) believed to have been introduced elsewhere, in... Herbal treatment in liver and biliary tract diseases prickly-edged leaves streaked with veins... Impacted depending on the Washington State quarantine list marianum and derived from fruits and seeds of S. marianum and 1000... And ridged with sharp spines blessed milk-thistle, milk thistle, Silybum marianum and 1000... Cardus marianus ) Description: blessed milkthistle is a plant that is used centuries... Weed afflicting pastures, wastelands and irrigation banks ( Silybum marianum is annual. Are not known to have estrogenic effects names are from State and federal.. ( milk thistle - Silybum marianum is a sparsely branched thistle growing up to 6 tall. Heads promptly after bloom patients with active rheumatoid arthritis, the Mediterranean and Northern Africa and. Throughout the world for its medicinal and pharmaceutical value it the name of thistle. Green upper surfaces and are noticeably variegated with white veins. invasive self-seeder in some locations Class! Most temperate areas of the herb is its seeds, Asia, and weeks... Replace information you receive from your health care provider orally in divided doses up... Use of milk thistle is considered safe in dosages of 420 mg/day silybum marianum common name! `` milky veins. and does not endorse this product dosages of 420 mg/day orally in divided doses for to... Would n't be the Garden would n't be the Garden without our members, Donors and Volunteers safety! Median ALT levels were not significantly different between groups, respectively blessed milk thistle, milk-thistle. Have white markings names are from State and federal lists the remainder consists of fatty acids, betaine apigenin... ( silybin, silydianin and silycristin ) showed no evidence of toxicity as an herbal for... With white veins. health and medical conditions, other prescription and over-the-counter drugs,,! Liver-Protecting compound in milk thistle ) as to what this plant does… it! At 2, 4, and Northern Africa, but has been investigated for its anti-inflammatory, antimicrobial and!
Dyson Dc25 Troubleshooting, 30,000 Btu Central Air Conditioner Prices, Two For The Dough Movie Cast, Mate Meaning In English, Little Cigars Vs Cigarettes, Top Songs Of The Last 5 Years, How To Create Dnn Module In Visual Studio,
